JNJ16259685
JNJ16259685 is a potent and selective mGluR1 antagonist, demonstrating concentration-dependent inhibition of synaptic mGluR1 activation with an IC50 of 19 nM. This compound is a valuable research tool for investigating the role of mGluR1 in neurological disorders, including pain, ataxia, and addiction, in both in vitro and in vivo models.
Product Specifications
CAS Number
409345-29-5
Product Name Alternative
.TN.T 16259685, .TN.T16259685, .TN.T-16259685, inhibit, JNJ 16259685, JNJ16259685, JNJ-16259685, Inhibitor, Metabotropic glutamate receptors, mGluR, mGluR1
Field of Research
Neuroscience
Purity
98.31% (May vary between batches)
Solubility
DMSO:100 mg/mL (307.31 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.29 mM)
Smiles
CO[C@H]1CC[C@H] (CC1) C (=O) c1ccc2nc3OCCCc3cc2c1
Molecular Formula
C20H23NO3
Molecular Weight
325.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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