YKL-06-061
YKL-06-061 is a potent and selective small-molecule inhibitor of salt-inducible kinases (SIKs), demonstrating high selectivity with IC50 values of 6.56 nM (SIK1), 1.77 nM (SIK2), and 20.5 nM (SIK3) . This compound is a valuable research tool for investigating SIK signaling pathways in both cellular and animal models of inflammation, fibrosis, and metabolic regulation.
Product Specifications
CAS Number
2172617-15-9
Product Name Alternative
Inhibit, Inhibitor, Salt-inducible Kinase (SIK), YKL 06 061, YKL06061, YKL-06-061, SIK1, SIK3, SIK2
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
99.52% (May vary between batches)
Solubility
DMSO:5.28 mg/mL (10.01 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.9 mM)
Smiles
COc1cc (ccc1Nc1ncc2CN (C (=O) N (C3CCC3) c2n1) c1c (C) cccc1C) N1CCN (C) CC1
Molecular Formula
C30H37N7O2
Molecular Weight
527.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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