Adavivint
Adavivint (SM04690) is a potent and selective small molecule inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM in a TCF/LEF reporter assay using SW480 cells. It is a valuable research tool for investigating Wnt pathway biology in vitro and has shown potential for modulating bone and cartilage regeneration in preclinical in vivo models.
Product Specifications
CAS Number
1467093-03-3
Product Name Alternative
Bcatenin, Adavivint, Adavivint (SM04690), betacatenin, beta-catenin, inhibit, Lorecivivint, Inhibitor, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, SM 04690, SM04690, SM-04690, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
≥98% (May vary between batches)
Solubility
DMSO:16.25 mg/mL (32.14 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.96 mM)
Smiles
CC (C) CC (=O) Nc1cncc (c1) -c1ccc2[nH]nc (-c3nc4cncc (-c5cccc (F) c5) c4[nH]3) c2c1
Molecular Formula
C29H24FN7O
Molecular Weight
505.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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