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Adavivint

Adavivint (SM04690) is a potent and selective small molecule inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM in a TCF/LEF reporter assay using SW480 cells. It is a valuable research tool for investigating Wnt pathway biology in vitro and has shown potential for modulating bone and cartilage regeneration in preclinical in vivo models.

Product Specifications

CAS Number

1467093-03-3

Product Name Alternative

Bcatenin, Adavivint, Adavivint (SM04690), betacatenin, beta-catenin, inhibit, Lorecivivint, Inhibitor, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, SM 04690, SM04690, SM-04690, βcatenin

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Purity

≥98% (May vary between batches)

Solubility

DMSO:16.25 mg/mL (32.14 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.96 mM)

Smiles

CC (C) CC (=O) Nc1cncc (c1) -c1ccc2[nH]nc (-c3nc4cncc (-c5cccc (F) c5) c4[nH]3) c2c1

Molecular Formula

C29H24FN7O

Molecular Weight

505.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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