Cafestol
Cafestol is a bioactive diterpene that inhibits ERK and NF-κB signaling, thereby suppressing LPS-induced COX-2 expression and PGE2 production in RAW264.7 macrophages. Its anti-inflammatory activity makes it a useful research tool for studying pathways involved in inflammation, both in vitro and in animal models.
Product Specifications
CAS Number
469-83-0
Product Name Alternative
Extracellular signal regulated kinases, ERK, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, NFkB, NF-kB, NFκB, inhibit, Inhibitor, CAFESTOL, Cyclooxygenase, COX, COX-2, Prostaglandin E synthase, PGESynthase, PGE synthase, PGE Synthase
Field of Research
Cell Biology
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml) .
Smiles
[H][C@@]12C[C@]3 (C[C@]1 (O) CO) CC[C@]1 ([H]) c4ccoc4CC[C@@]1 (C) [C@]3 ([H]) CC2
Molecular Formula
C20H28O3
Molecular Weight
316.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1S,4S,12S,13R,16R,17R) -17- (hydroxymethyl) -12-methyl-8-oxapentacyclo- [14.2.1.01,13.04,12.05,9]nonadeca-5 (9),6-dien-17-ol
Available Sizes
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