GPX4-IN-4
GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1].
Product Specifications
CAS Number
[2920221-53-8]
UNSPSC
12352005
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-4.html
Concentration
10mM
Purity
98.94
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
COC([C@H]1CC2=C([C@@H](N1C(CCl)=O)C3=CC=C(C=C3)S(C)(=O)=O)NC4=CC=CC=C42)=O
Molecular Formula
C22H21ClN2O5S
Molecular Weight
460.93
References & Citations
[1]Randolph JT, et al. Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo. J Med Chem. 2023 Mar 23;66 (6) :3852-3865.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Curated Selection
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