Bevirimat
Bevirimat (PA-457) is a first-in-class maturation inhibitor that specifically targets HIV-1 by blocking the proteolytic cleavage of the CA-SP1 Gag precursor, thereby preventing the formation of mature CA protein and inhibiting viral infectivity. This mechanism has been validated in both in vitro antiviral assays and in vivo studies using SCID-hu mouse models, supporting its role as a key research tool for investigating late-stage HIV replication.
Product Specifications
CAS Number
174022-42-5
Product Name Alternative
YK FH 312, YK FH312, YK FH-312, Bevirimat, HIV, HIVProtease, HIV Protease, HIV-1, Human immunodeficiency virus, Inhibitor, inhibit, MPC 4326, MPC4326, MPC-4326, PA457, PA-457, PA 457
Field of Research
Infectious Disease & Virology, Protein Biochemistry
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM) ; DMSO:50 mg/mL (85.49 mM)
Smiles
[H][C@]12[C@@H] (CC[C@@]1 (CC[C@]1 (C) [C@]2 ([H]) CC[C@]2 ([H]) [C@@]3 (C) CC[C@H] (OC (=O) CC (C) (C) C (O) =O) C (C) (C) [C@]3 ([H]) CC[C@@]12C) C (O) =O) C (C) =C
Molecular Formula
C36H56O6
Molecular Weight
584.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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