BC-1215
BC-1215 is a potent small molecule inhibitor of the E3 ubiquitin ligase component FBXO3, demonstrating an IC50 of 0.9 μg/mL for inhibiting IL-1β release. This compound is a valuable research tool for studying inflammatory pathways and has been utilized in both cellular and animal models to investigate diseases driven by dysregulated proteasomal degradation.
Product Specifications
CAS Number
1507370-20-8
Product Name Alternative
TRAF, U937 cells, E3 ligase-recruiting Moiety, BC1215, BC-1215, BC 1215, FBXO3, F-box protein 3 (Fbxo3), Inhibitor, PBMC cells, MLE cells, LigandforE3Ligase, Ligands for E3 Ligase, Ligand for E3 Ligase, inhibit, inflammation
Field of Research
Pharmacology & Drug Discovery
Purity
≥95% (May vary between batches)
Solubility
DMSO:3.95 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.53 mM)
Smiles
C (CNCc1ccc (cc1) -c1ccccn1) NCc1ccc (cc1) -c1ccccn1
Molecular Formula
C26H26N4
Molecular Weight
394.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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