SM 16
SM 16 is a potent and selective small molecule inhibitor of ALK5 and ALK4 kinases, with respective Ki values of 10 nM and 1.5 nM. It is widely used in biochemical and cellular research to investigate TGF-β and activin signaling pathways in fibrosis, cancer, and developmental biology studies.
Product Specifications
CAS Number
614749-78-9
Product Name Alternative
Smad, SM16, SM-16, SM 16, TGFbeta, TGF-b/Smad, TGFb, TGF-β/Smad, TGFβ, TGF-β Receptor, TGF-beta, TGFbeta/Smad, Transforming growth factor beta receptors, ALK5, ALK4, inhibit, Inhibitor
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.72% (May vary between batches)
Solubility
DMSO:6.25 mg/mL (14.52 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.32 mM)
Smiles
Cc1cccc (n1) -c1[nH]c (nc1-c1ccc2OCOc2c1) C12CCC (CC1) (CC2) C (N) =O
Molecular Formula
C25H26N4O3
Molecular Weight
430.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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