Neoline
Neoline, an active component from A. venetum root (PA), alleviates oxaliplatin-induced peripheral neuropathy in murine models by inhibiting Nav1.7 voltage-gated sodium channels. This small molecule serves as a useful analytical marker for PA product quality in neuropathic pain research, with applications in both in vivo behavioral studies and in vitro electrophysiology assays.
Product Specifications
CAS Number
466-26-2
Product Name Alternative
Bullatine B, Inhibitor, pain, neuropathic, neuropathy, Neoline, Nav1.7 channel, inhibit, peripheral, oxaliplatin-induced, SodiumChannel, Sodium Channel
Field of Research
Pharmacology & Drug Discovery
Purity
98.72% (May vary between batches)
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.43 mM) ; DMSO:200 mg/mL (457.07 mM)
Smiles
[H][C@]12C[C@]3 ([H]) [C@] ([H]) ([C@H]1O) [C@] (O) (C[C@@H]2OC) [C@@]1 ([H]) [C@H] (OC) [C@@]2 ([H]) C33[C@@H] (O) CC[C@@]2 (COC) CN (CC) [C@]13[H]
Molecular Formula
C24H39NO6
Molecular Weight
437.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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