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(±) -Praeruptorin A

Praeruptorin A is a bioactive small molecule that inhibits osteoclast formation and bone resorption by targeting Ca2+/calmodulin and suppressing the p38/Akt-c-Fos-NFATc1 and CaMKIV/calcineurin-NFATc1 signaling pathways. It also upregulates MRP2 via CAR, indicating potential herb-drug interactions, making it a valuable tool for bone metabolism and drug transport research.

Product Specifications

CAS Number

73069-25-7

Product Name Alternative

Praeruptorin A, p38, p38 MAPK, p38MAPK, CalciumChannel, Calcium Channel, Ca channels, Ca2+ channels, (-) -Praeruptorin A, (±) Praeruptorin A, (±) -Praeruptorin A, (±) Praeruptorin A, Akt, Inhibitor, inhibit

Field of Research

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.90% (May vary between batches)

Solubility

Ethanol:Soluble; DMSO:70.00 mg/mL (181.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (5.18 mM) ; Pyridine, Methanol, etc.:Soluble

Smiles

C\C=C (\C) C (=O) O[C@@H]1[C@H] (OC (C) =O) c2c (OC1 (C) C) ccc1ccc (=O) oc21

Molecular Formula

C21H22O7

Molecular Weight

386.40

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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