(±) -Praeruptorin A
Praeruptorin A is a bioactive small molecule that inhibits osteoclast formation and bone resorption by targeting Ca2+/calmodulin and suppressing the p38/Akt-c-Fos-NFATc1 and CaMKIV/calcineurin-NFATc1 signaling pathways. It also upregulates MRP2 via CAR, indicating potential herb-drug interactions, making it a valuable tool for bone metabolism and drug transport research.
Product Specifications
CAS Number
73069-25-7
Product Name Alternative
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.90% (May vary between batches)
Solubility
Ethanol:Soluble; DMSO:70.00 mg/mL (181.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (5.18 mM) ; Pyridine, Methanol, etc.:Soluble
Smiles
C\C=C (\C) C (=O) O[C@@H]1[C@H] (OC (C) =O) c2c (OC1 (C) C) ccc1ccc (=O) oc21
Molecular Formula
C21H22O7
Molecular Weight
386.40
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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