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E6446 dihydrochloride

E6446 dihydrochloride is a potent and selective synthetic antagonist of nucleic acid-sensing Toll-like receptors (TLRs) . It inhibits DNA-induced TLR9 signaling in HEK293 cells with an IC50 of 10 nM, making it a valuable tool for studying innate immune pathways in vitro and in vivo models of autoimmune and inflammatory diseases.

Product Specifications

CAS Number

1345675-25-3

Product Name Alternative

E6446, E-6446, E6446 dihydrochloride, E6446 Dihydrochloride, E-6446 Dihydrochloride, E-6446 dihydrochloride, E 6446, E 6446 Dihydrochloride, TLR

Field of Research

Immunology & Inflammation, Metabolism Research

Purity

98.44% (May vary between batches)

Solubility

DMSO:5.23 mg/mL (10.01 mM)

Smiles

Cl.Cl.C (COc1ccc (cc1) -c1nc2ccc (OCCCN3CCCC3) cc2o1) CN1CCCC1

Molecular Formula

C27H37Cl2N3O3

Molecular Weight

522.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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