E6446 dihydrochloride
E6446 dihydrochloride is a potent and selective synthetic antagonist of nucleic acid-sensing Toll-like receptors (TLRs) . It inhibits DNA-induced TLR9 signaling in HEK293 cells with an IC50 of 10 nM, making it a valuable tool for studying innate immune pathways in vitro and in vivo models of autoimmune and inflammatory diseases.
Product Specifications
CAS Number
1345675-25-3
Product Name Alternative
E6446, E-6446, E6446 dihydrochloride, E6446 Dihydrochloride, E-6446 Dihydrochloride, E-6446 dihydrochloride, E 6446, E 6446 Dihydrochloride, TLR
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
98.44% (May vary between batches)
Solubility
DMSO:5.23 mg/mL (10.01 mM)
Smiles
Cl.Cl.C (COc1ccc (cc1) -c1nc2ccc (OCCCN3CCCC3) cc2o1) CN1CCCC1
Molecular Formula
C27H37Cl2N3O3
Molecular Weight
522.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
EKN45872 96 Tests
Mouse Hepatoma Derived Growth Factor (HDGF) ELISA Kit
Sign In for Pricing
View Details 