E6446 dihydrochloride
E6446 dihydrochloride is a potent and selective synthetic antagonist of nucleic acid-sensing Toll-like receptors (TLRs) . It inhibits DNA-induced TLR9 signaling in HEK293 cells with an IC50 of 10 nM, making it a valuable tool for studying innate immune pathways in vitro and in vivo models of autoimmune and inflammatory diseases.
Product Specifications
CAS Number
1345675-25-3
Product Name Alternative
E6446, E-6446, E6446 dihydrochloride, E6446 Dihydrochloride, E-6446 Dihydrochloride, E-6446 dihydrochloride, E 6446, E 6446 Dihydrochloride, TLR
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
98.44% (May vary between batches)
Solubility
DMSO:5.23 mg/mL (10.01 mM)
Smiles
Cl.Cl.C (COc1ccc (cc1) -c1nc2ccc (OCCCN3CCCC3) cc2o1) CN1CCCC1
Molecular Formula
C27H37Cl2N3O3
Molecular Weight
522.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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