SJ6986
SJ6986 is a potent, selective, and orally bioavailable molecular glue degrader of GSPT1/2, achieving maximal degradation (Dmax 99%) with a DC50 of 2.1 nM. This compound is a valuable chemical probe for investigating targeted protein degradation mechanisms in oncology research, supporting both in vitro and in vivo studies of cancers dependent on GSPT1/2 function.
Product Specifications
CAS Number
2765625-93-0
Product Name Alternative
SJ 6986, SJ6986, SJ-6986
Field of Research
Pharmacology & Drug Discovery
Purity
99.45% (May vary between batches)
Solubility
DMSO:55 mg/mL (110.57 mM) ;10% DMSO+90% Saline:2.5 mg/mL (5.03 mM)
Smiles
O=C1N (C (=O) C=2C1=CC (NS (=O) (=O) C3=C (OC (F) (F) F) C=CC=C3) =CC2) C4C (=O) NC (=O) CC4
Molecular Formula
C20H14F3N3O7S
Molecular Weight
497.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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