CBL0137
CBL0137 is a metabolically stable curaxin that potently activates p53 and inhibits NF-κB by inactivating the FACT complex. It demonstrates broad in vivo anticancer activity, eradicates resistant cancer stem cells, and synergizes with gemcitabine in preclinical pancreatic cancer models.
Product Specifications
CAS Number
1197996-80-7
Product Name Alternative
NFkB, NF-kB, NFκB, NF-κB, p53, CBLC 137, CBL0137, CBL-0137, CBLC137, CBLC-137, CBL 0137, Curaxin 137
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.94 mM) ; DMSO:25 mg/mL (74.31 mM)
Smiles
C (CNC (C) C) N1C=2C (C=3C1=CC=C (C (C) =O) C3) =CC (C (C) =O) =CC2
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
Storage Conditions
-20°C
Notes
For research use only.
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