Sacubitril hemicalcium salt
Sacubitril hemicalcium salt (AHU377) is a potent prodrug neprilysin (NEP) inhibitor (IC50 = 5 nM) metabolized to active LBQ657. As a key component of LCZ696 (valsartan/sacubitril), it is widely used in cardiovascular research, particularly in studies of hypertension and heart failure, to investigate NEP inhibition's effects on natriuretic peptides in vitro and in animal models.
Product Specifications
CAS Number
1369773-39-6
Product Name Alternative
Neprilysin, NEP, neutral endopeptidase (NEP), Neutral endopeptidase, inhibit, Inhibitor, AHU377, AHU-377, AHU-377 (hemicalcium salt), AHU377 calcium salt, AHU377 calcium, AHU-377 hemicalcium, AHU 377, Cluster of differentiation 10, CD10, Sacubitril hemicalcium, Sacubitril hemicalcium salt, Sacubitril
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.28% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.81 mM) ; DMSO:60 mg/mL (69.68 mM)
Smiles
[Ca++].CCOC (=O) [C@H] (C) C[C@@H] (Cc1ccc (cc1) -c1ccccc1) NC (=O) CCC ([O-]) =O.CCOC (=O) [C@H] (C) C[C@@H] (Cc1ccc (cc1) -c1ccccc1) NC (=O) CCC ([O-]) =O
Molecular Formula
C48H56CaN2O10
Molecular Weight
861.06
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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