E6446
E6446 is a small molecule inhibitor of Toll-like receptors 7 and 9 (TLR7/9) that blocks DNA-TLR9 interaction in vitro. In vivo, it suppresses immune responses to CpG DNA challenge in mice, making it a useful research tool for studying TLR signaling in autoimmunity and inflammation models.
Product Specifications
CAS Number
1219925-73-1
Product Name Alternative
E6446, E-6446, E 6446, TLR7, TLR9
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
98.72% (May vary between batches)
Solubility
DMSO:9 mg/mL (20.02 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.11 mM)
Smiles
O (CCCN1CCCC1) C=2C=C3C (N=C (O3) C4=CC=C (OCCCN5CCCC5) C=C4) =CC2
Molecular Formula
C27H35N3O3
Molecular Weight
449.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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