SAR-20347
SAR-20347 is a potent small molecule inhibitor targeting the TYK2, JAK1, JAK2, and JAK3 kinases with respective IC50 values of 0.6, 23, 26, and 41 nM. This compound is a valuable research tool for investigating JAK/STAT signaling pathways in both cellular and animal models of autoimmune and inflammatory diseases.
Product Specifications
CAS Number
1450881-55-6
Product Name Alternative
SAR20347, SAR-20347, SAR 20347, TyrosineKinases, Tyrosine Kinases, TYK2, JAK, JAK1, Janus kinase, inhibit, JAK2, JAK3, Inhibitor
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.99% (May vary between batches)
Solubility
DMSO:55 mg/mL (123.64 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM)
Smiles
NC (=O) c1nc (oc1Nc1ccc (cc1) C (=O) N1CCOCC1) -c1c (F) cccc1Cl
Molecular Formula
C21H18ClFN4O4
Molecular Weight
444.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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