I-CBP112 hydrochloride
I-CBP112 is a potent and selective small molecule inhibitor of the CBP/p300 bromodomains. It reduces the leukemia-initiating potential of MLL-AF9+ AML cells in vitro and in vivo and shows synergistic effects with BET inhibitors like JQ1 and chemotherapeutics such as doxorubicin in oncology research.
Product Specifications
CAS Number
2147701-33-3
Product Name Alternative
CBP/p300, Leukemia cell, CBP/p300, Prostate cancer cell, Inhibitor, I-CBP 112 Hydrochloride, I-CBP112, ICBP112 hydrochloride, I-CBP112 Hydrochloride, I-CBP-112 hydrochloride, I-CBP-112 Hydrochloride, I CBP112 hydrochloride, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit
Field of Research
Epigenetics & Chromatin
Purity
97.98% (May vary between batches)
Solubility
DMSO:60 mg/mL (118.8 mM)
Smiles
O (C[C@@H]1CN (C) CCC1) C2=C3C (=CC (=C2) C4=CC (OC) =C (OC) C=C4) CN (C (CC) =O) CCO3.Cl
Molecular Formula
C27H37ClN2O5
Molecular Weight
505.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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