Isofraxidin
Isofraxidin, a bioactive coumarin, demonstrates radioprotective effects in leukemia cells via ROS-mitochondrial pathways and alleviates LPS-induced acute lung injury by suppressing COX-2/PGE2. Its analgesic and anti-inflammatory properties are linked to modulating TNF-α and inhibiting p38/ERK1/2 phosphorylation, supporting research in oncology, immunology, and inflammation using in vitro and murine models.
Product Specifications
CAS Number
486-21-5
Product Name Alternative
ERK, ERK1/2, hepatoma, iNOS, Inhibitor, MD-2, Matrix metalloproteinases, invasion, inhibit, Isofraxidin, MMP, MMP-7, Cyclooxygenase, cell, COX, COX-2, 6,8-Dimethoxyumbelliferone, TLR, TLR4, Phytodolor, p38MAPK, p38, p38 MAPK, Toll-like Receptor (TLR)
Field of Research
Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble; DMSO:40 mg/mL (180.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9 mM)
Smiles
COc1cc2ccc (=O) oc2c (OC) c1O
Molecular Formula
C11H10O5
Molecular Weight
222.19
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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