Isofraxidin

Isofraxidin, a bioactive coumarin, demonstrates radioprotective effects in leukemia cells via ROS-mitochondrial pathways and alleviates LPS-induced acute lung injury by suppressing COX-2/PGE2. Its analgesic and anti-inflammatory properties are linked to modulating TNF-α and inhibiting p38/ERK1/2 phosphorylation, supporting research in oncology, immunology, and inflammation using in vitro and murine models.

Product Specifications

CAS Number

486-21-5

Product Name Alternative

ERK, ERK1/2, hepatoma, iNOS, Inhibitor, MD-2, Matrix metalloproteinases, invasion, inhibit, Isofraxidin, MMP, MMP-7, Cyclooxygenase, cell, COX, COX-2, 6,8-Dimethoxyumbelliferone, TLR, TLR4, Phytodolor, p38MAPK, p38, p38 MAPK, Toll-like Receptor (TLR)

Field of Research

Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction

Purity

≥95% (May vary between batches)

Solubility

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble; DMSO:40 mg/mL (180.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9 mM)