CFT7455
CFT7455 (Cemsidomide) is a potent, orally bioavailable cereblon E3 ligase binder (Kd = 0.9 nM) that induces the degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) . It is a research compound for studying hematological cancers, with demonstrated activity in both cellular assays and in vivo models.
Product Specifications
CAS Number
2504235-67-8
Product Name Alternative
Anti-cancer agent, CFT7455, CFT-7455, CFT 7455, cereblon, cereblon (CRBN) E3 ligase, Cemsidomide, E3 ligase-recruiting Moiety, inhibit, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, orally active, Inhibitor, IKZF1, IKZF3 degrader
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
97.93% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.26 mM) ; DMSO:20 mg/mL (42.6 mM)
Smiles
[H][C@@]1 (CCC (=O) NC1=O) N1C (=O) c2cccc3c (Cc4ccc (CN5CCOCC5) cc4) ccc1c23
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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