Lysophosphatidic Acid Receptor 2 (EDG-4)
Product Specifications
Background
EDG4 (LPA2) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.
Synonyms
EDG4 (LPA2) Transfected Cell Positive Control Lysate
Conjugation
Unconjugated
Type
Control Lysate
Applications
WB
Field of Research
Ancillary Reagents
Assay Principle
For use as a positive control with Exalpha's EDG4 (NT) monoclonal antibody (Cat. No. C180M) for Western blot analysis. Will not work with EDG4 (CT) antibody (Cat. No. C181M).. Grown in RH7 cells.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided in 10% glycerol, 0,063 M Tris-HCl (pH 6,8), 2% SDS and 0,002% bromophenol blue, 5% 2-mercaptoethanol
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
Curated Selection
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