GSK4112
GSK4112 (SR6452) is a potent and selective synthetic agonist of the nuclear receptor Rev-erbα, demonstrating an EC50 of 0.4 μM. This chemical probe is widely used in vitro and in vivo to investigate circadian rhythm regulation, metabolic pathways, and inflammatory responses linked to Rev-erbα biology.
Product Specifications
CAS Number
1216744-19-2
Product Name Alternative
SR-6452
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Rev-Erbalpha agonist
Form
Powder
Solubility
Soluble in DMSO (50 mg/ml)
Smiles
CC (C) (C) OC (=O) CN (Cc1ccc (s1) [N+] ([O-]) =O) Cc1ccc (Cl) cc1
Molecular Formula
C18H21ClN2O4S
Molecular Weight
396.9
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[ (4-Chlorophenyl) methyl]-N-[ (5-nitro-2-thienyl) methyl]-glycine, 1,1-dimethylethyl ester
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