Gefapixant
Gefapixant (AF219) is a selective P2X3 receptor antagonist, exhibiting IC50 values of approximately 30 nM at human P2X3 homotrimers and 100-250 nM at P2X2/3 heterotrimers. This investigational compound is widely used in preclinical in vitro and in vivo research for studying purinergic signaling, chronic cough mechanisms, and airway hypersensitivity.
Product Specifications
CAS Number
1015787-98-0
Product Name Alternative
RO4926219, RO-4926219, RO 4926219, P2XRs, P2XReceptor, P2X3, P2X Receptor, Inhibitor, Gefapixant, MK 7264, MK7264, MK-7264, knee osteoarthritis, inhibit, chronic cough, AF219, AF-219, AF 219
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.26% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
COc1cc (C (C) C) c (Oc2cnc (N) nc2N) cc1S (N) (=O) =O
Molecular Formula
C14H19N5O4S
Molecular Weight
353.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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