Avapritinib
Avapritinib (BLU-285) is a potent, oral inhibitor targeting mutant KIT (D816V) and PDGFRA (D842V) kinases with sub-nanomolar IC50 values. It also inhibits ABCB1 and ABCG2 transporters. This agent demonstrates antitumor efficacy in research models of systemic mastocytosis and gastrointestinal stromal tumors (GIST) .
Product Specifications
CAS Number
1703793-34-3
Product Name Alternative
BLU 285, BLU285, BLU-285, Avapritinib, cKit, c-Kit, CD117, inhibit, PDGFR, Platelet-derived growth factor receptor, Inhibitor, PDGFRα, SCFR
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
96.59% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.02 mM) ; Ethanol:3 mg/mL (6.02 mM) ; DMSO:120 mg/mL (240.69 mM)
Smiles
Cn1cc (cn1) -c1cc2c (ncnn2c1) N1CCN (CC1) c1ncc (cn1) [C@@] (C) (N) c1ccc (F) cc1
Molecular Formula
C26H27FN10
Molecular Weight
498.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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