CZC-25146 hydrochloride
CZC-25146 is a potent and selective LRRK2 kinase inhibitor, demonstrating IC50 values of 4.76 nM and 6.87 nM against wild-type and the Parkinson's disease-linked G2019S mutant, respectively. This tool compound is useful for investigating LRRK2 biology in cellular models and has been employed in preclinical studies to probe neuroinflammation and mitophagy pathways.
Product Specifications
CAS Number
1330003-04-7
Product Name Alternative
CZC 25146, CZC 25146 Hydrochloride, CZC 25146 hydrochloride, CZC25146, CZC-25146, CZC25146 Hydrochloride, CZC25146 hydrochloride, CZC-25146 Hydrochloride, Parkinson's disease, neurons, liver diseases, LRRK2 (WT), LRRK2 G2019S, LRRK2 (G2019S), LRRK2, inflammatory, inhibit, Leucine-rich repeat kinase 2, Inhibitor
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Purity
98.76% (May vary between batches)
Solubility
DMSO:55 mg/mL (104.76 mM)
Smiles
Cl.COc1cc (ccc1Nc1ncc (F) c (Nc2ccccc2NS (C) (=O) =O) n1) N1CCOCC1
Molecular Formula
C22H26ClFN6O4S
Molecular Weight
525
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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