EGFR-IN-12
EGFR-IN-12 is a potent and selective cell-permeable inhibitor of EGFR kinase, demonstrating an IC50 of 21 nM. It effectively suppresses EGFR autophosphorylation in cellular assays and is a valuable tool for investigating EGFR-driven signaling pathways in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
879127-07-8
Product Name Alternative
4,6-disubstituted, AKT, anti-proliferation, antitumor, autophosphorylation, Apoptosis, inhibit, kinases, Inhibitor, HER1, Epidermal growth factor receptor, EGFR (L861Q), EGFR (L858R), EGFR IN 12, EGFRIN12, EGFR-IN-12, EGFR Inhibitor, EGFR, ErbB-1, pyrimidine, Tyrosine
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.30% (May vary between batches)
Solubility
Ethanol:10 mg/mL (24.19 mM) ; DMSO:50 mg/mL (120.95 mM)
Smiles
FC (F) (F) c1cccc (Nc2cc (Nc3cccc (NC (=O) C4CC4) c3) ncn2) c1
Molecular Formula
C21H18F3N5O
Molecular Weight
413.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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