AZ304
AZ304 is a potent ATP-competitive dual inhibitor of BRAF and CRAF kinases, with IC50 values of 79, 38, and 68 nM for BRAF (WT), BRAF (V600E), and CRAF (WT), respectively. It is a valuable research tool for investigating MAPK pathway signaling in both cellular and animal models of cancers driven by RAF mutations.
Product Specifications
CAS Number
942507-42-8
Product Name Alternative
Raf kinases, Raf, p38MAPK, p38, p38 MAPK, inhibit, Inhibitor, Autophagy, AZ304, AZ-304, AZ 304, B-Raf (V600E), B-Raf (WT), cFms, CSF1R
Field of Research
Cell Biology, Signal Transduction
Purity
99.82% (May vary between batches)
Solubility
DMSO:50 mg/mL (110.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.43 mM) ; H2O:Insoluble; Ethanol:4 mg/mL (8.86 mM)
Smiles
COc1ccc2c (Nc3cc (NC (=O) c4cccc (c4) C (C) (C) C#N) ccc3C) ncnc2c1
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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