Asciminib
Asciminib (ABL001) is a highly potent and selective allosteric Bcr-Abl inhibitor with sub-nanomolar binding affinity. It is widely used in research for chronic myeloid leukemia (CML), demonstrating efficacy in both cellular assays and in vivo models to study resistance mechanisms and therapeutic strategies.
Product Specifications
CAS Number
1492952-76-7
Product Name Alternative
Bcr-Abl, BcrAbl, Asciminib, ABL 001, ABL001, ABL-001, Abl1, inhibit, Inhibitor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.93% (May vary between batches)
Solubility
H2O:Insoluble; DMSO:245 mg/mL (544.64 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM)
Smiles
C (NC1=CC=C (OC (Cl) (F) F) C=C1) (=O) C2=CC (=C (N=C2) N3CC[C@@H] (O) C3) C=4C=CNN4
Molecular Formula
C20H18ClF2N5O3
Molecular Weight
449.84
Storage Conditions
-20°C
Notes
For research use only.
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