GS-444217
GS-444217 is a potent and selective ATP-competitive inhibitor of ASK1 (apoptosis signal-regulating kinase 1), exhibiting an IC50 of 2.87 nM. This small molecule is a valuable research tool for investigating the role of ASK1 in cellular stress responses, inflammation, and fibrotic diseases in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1262041-49-5
Product Name Alternative
Apoptosis, ASK1, MAP3K, MAP kinase kinase kinase, MEKK, MAPKKK, Inhibitor, GS 444217, GS444217, GS-444217, inhibit
Field of Research
Cell Biology, Signal Transduction
Purity
99.08% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.86 mM) ; DMSO:55 mg/mL (133.67 mM)
Smiles
O=C (Nc1cccc (c1) -c1nncn1C1CC1) c1cc (ccn1) -n1cnc (c1) C1CC1
Molecular Formula
C23H21N7O
Molecular Weight
411.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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