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PF-9366

PF-9366 is a potent and selective small molecule inhibitor of methionine adenosyltransferase 2A (MAT2A), exhibiting an IC50 of 420 nM and a Kd of 170 nM. It is a valuable chemical probe for researching methyl metabolism in cancers, with utility in both in vitro biochemical assays and in vivo xenograft studies.

Product Specifications

CAS Number

72882-78-1

Product Name Alternative

MAT, Mat2A, Inhibitor, MethionineAdenosyltransferase, MethionineAdenosyltransferase (MAT), Methionine Adenosyltransferase, Methionine Adenosyltransferase (MAT), inhibit, PF 9366, PF9366, PF-9366

Field of Research

Epigenetics & Chromatin

Purity

>98%

Bioactivity

Methionine adenosyltransferase 2A inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to 20 mg/ml)

Smiles

CN (C) CCc1nnc2cc (-c3ccccc3) c3cc (Cl) ccc3n12

Molecular Formula

C20H19ClN4

Molecular Weight

350.85

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

2- (7-Chloro-5-phenyl) -[1,2,4]triazolo[4,3-a]quinoline-1-yl) -N, N, dimethylethanamine

Available Sizes

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