Sparsentan
Sparsentan (DARA-a) is a first-in-class, orally active small molecule that potently antagonizes both endothelin A (Ki=9.3 nM) and angiotensin II (Ki=0.8 nM) receptors. It is a valuable research tool for investigating fibrotic diseases, including focal segmental glomerulosclerosis (FSGS), in both in vitro and in vivo models.
Product Specifications
CAS Number
254740-64-2
Product Name Alternative
DARA-a, Angiotensin Receptor, angiotensin II receptor, EndothelinReceptor, Endothelin Receptor, Endothelin A receptor, inhibit, Inhibitor, Sparsentan, RE021, RE-021, RE 021
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
97.94% (May vary between batches)
Solubility
DMSO:260 mg/mL (438.63 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.37 mM)
Smiles
CCCCC1=NC2 (CCCC2) C (=O) N1Cc1ccc (c (COCC) c1) -c1ccccc1S (=O) (=O) Nc1noc (C) c1C
Molecular Formula
C32H40N4O5S
Molecular Weight
592.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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