Letermovir
Letermovir (AIC246) is a potent antiviral agent targeting cytomegalovirus (CMV) by inhibiting the pUL56 subunit of the viral terminase complex, demonstrating an EC50 of approximately 5 nM in fibroblast assays. It is a valuable research tool for investigating CMV replication mechanisms and has shown efficacy in both in vitro and in vivo models for prophylaxis.
Product Specifications
CAS Number
917389-32-3
Product Name Alternative
Inhibitor, HCMV, HCV Protease, HCVProtease, Letermovir, MK8828, MK-8828, MK 8828, inhibit, AIC 246, AIC246, AIC-246, CMV, Cytomegalovirus
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
99.85% (May vary between batches)
Solubility
Ethanol:2 mg/mL (3.49 mM) ; DMSO:70 mg/mL (122.26 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.49 mM)
Smiles
COc1cccc (c1) N1CCN (CC1) C1=Nc2c (F) cccc2[C@H] (CC (O) =O) N1c1cc (ccc1OC) C (F) (F) F
Molecular Formula
C29H28F4N4O4
Molecular Weight
572.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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