BMS 599626 2HCl
BMS 599626 dihydrochloride (CAS 873837-23-1 (HCl) ), also known as AC480 dihydrochloride, is a potent and selective ATP-competitive inhibitor of HER1/EGFR and HER2 tyrosine kinases, with IC50 values of 20 nM and 30 nM, respectively. It demonstrates significantly weaker activity against HER4 and many other kinases. This compound has been utilized in preclinical research to investigate HER-driven tumorigenesis in both cellular and animal models.
Product Specifications
CAS Number
1781932-33-9
Product Name Alternative
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.94% (May vary between batches)
Solubility
H2O:3 mg/mL (4.97 mM) ; DMSO:95 mg/mL (157.42 mM)
Smiles
O=C (OC[C@@H]1COCCN1) NC2=CN3C (C (NC4=CC=C (N (N=C5) CC6=CC (F) =CC=C6) C5=C4) =NC=N3) =C2C.Cl.Cl
Molecular Formula
C27H29FN8O3Cl2
Molecular Weight
603.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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