RO4987655
RO4987655 (RG7167) is a potent and selective oral MEK1/2 inhibitor with an IC50 of 5.2 nM. It is a valuable research tool for investigating the MAPK/ERK pathway in oncology, with demonstrated utility in both in vitro cellular assays and in vivo tumor model studies.
Product Specifications
CAS Number
874101-00-5
Product Name Alternative
CH 4987655, CH4987655, CH-4987655, MAPKK, MAP2K, MEK2, MEK1, MEK, Inhibitor, inhibit, Mitogen-activated protein kinase kinase, RO4987655, RO-4987655, RO 4987655, RG7167, RG-7167, RG 7167
Field of Research
Signal Transduction
Purity
98.21% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.54 mM) ; DMSO:35 mg/mL (61.92 mM)
Smiles
OCCONC (=O) c1cc (CN2OCCCC2=O) c (F) c (F) c1Nc1ccc (I) cc1F
Molecular Formula
C20H19F3IN3O5
Molecular Weight
565.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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