ML216
ML216 (CID-49852229) is a potent and selective inhibitor of the BLM helicase with an IC50 of 1.8 μM, demonstrating over 28-fold selectivity against RECQ1, RECQ5, and E. coli UvrD. This tool compound is used in vitro to study DNA repair mechanisms, replication stress, and genomic instability associated with Bloom syndrome.
Product Specifications
CAS Number
1430213-30-1
Product Name Alternative
Inhibit, ML216, ML-216, ML 216, Inhibitor, helicase, DNA, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, chromatid, CID 49852229, CID49852229, CID-49852229, BLM helicase, BLM, anti-proliferative, Anticancer, sister, WRN, RNASynthesis, RNA Synthesis, toxicity, unwinding
Field of Research
Cell Biology, Molecular Biology
Purity
96.83% (May vary between batches)
Solubility
DMSO:5 mg/mL (13.04 mM)
Smiles
Fc1ccc (NC (=O) Nc2nnc (s2) -c2ccncc2) cc1C (F) (F) F
Molecular Formula
C15H9F4N5OS
Molecular Weight
383.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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