1-Aminocyclopropane-1-carboxylic acid

1-Aminocyclopropane-1-carboxylic acid (ACC) is a dual-acting NMDA receptor modulator, serving as a glycine-site agonist at low glutamate and a glutamate-site antagonist at high glutamate. This unique profile underlies its neuroprotective effects in in vivo ischemia models, where it moderates receptor activity to prevent excitotoxicity. It is also a key biosynthetic precursor to the plant hormone ethylene.