Retapamulin

Retapamulin (SB-275833) is a potent pleuromutilin antibiotic that binds with high affinity (Kd ~3 nM) to the ribosomes of both Gram-positive and Gram-negative bacteria like S. aureus and E. coli. It is a valuable tool for studying bacterial protein synthesis inhibition in vitro and has demonstrated efficacy in models of topical skin infection.

Product Specifications

CAS Number

224452-66-8

Product Name Alternative

Inhibit, Inhibitor, Antibiotic, Bacterial, ribosome, Retapamulin, SB 275833, SB275833, SB-275833

Field of Research

Infectious Disease & Virology, Pharmacology & Drug Discovery

Purity

99.57% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:104 mg/mL (200.87 mM) ; DMSO:18.33 mg/mL (35.4 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM)