(S) - (+) -Rolipram
(+) -Rolipram is a selective PDE4 inhibitor with an IC50 of 0.75 μM against the human monocyte enzyme. This compound exhibits anti-inflammatory and CNS antidepressant activities in research models, though it is less potent than its (R) -enantiomer. It is widely used in vitro and in vivo to study PDE4 biology and inflammation-related pathways.
Product Specifications
CAS Number
85416-73-5
Product Name Alternative
(S) -Rolipram, (S) (+) Rolipram, (S) (+) Rolipram, (+) -Rolipram, Apoptosis, cAMP, necrosis, PDE4, inhibit, mononuclear, Inhibitor, factor, Phosphodiesterase (PDE), phosphodiesterase, TNFα, Rolipram, S- Rolipram, S- (+) -Rolipram, tumor
Field of Research
Cell Biology, Metabolism Research
Purity
99.14% (May vary between batches)
Solubility
DMSO:27.5 mg/mL (99.88 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.26 mM)
Smiles
COc1ccc (cc1OC1CCCC1) [C@H]1CNC (=O) C1
Molecular Formula
C16H21NO3
Molecular Weight
275.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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