SKI II
SKI-II is a potent and selective non-ATP-competitive inhibitor of sphingosine kinase 1 (SphK1) with an IC50 of 0.5 μM, showing no activity against PKCα, PI3K, or ERK2. This tool compound is widely used in vitro and in vivo to investigate the S1P signaling pathway in cancer, inflammation, and angiogenesis research.
Product Specifications
CAS Number
312636-16-1
Product Name Alternative
S1PReceptor, S1P Receptor, SKI II, Sphingosine kinase, SphK-I2, SphK1, SphK, Wnt/b-catenin, Wnt, Wnt/β-catenin, Wnt/betacatenin, βcatenin, inhibit, Inhibitor, beta-catenin, betacatenin, bcatenin, Apoptosis
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.34% (May vary between batches)
Solubility
DMSO:40 mg/mL (132.11 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM)
Smiles
Oc1ccc (Nc2nc (cs2) -c2ccc (Cl) cc2) cc1
Molecular Formula
C15H11ClN2OS
Molecular Weight
302.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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