Tasquinimod

Tasquinimod (ABR-215050) is an orally active small molecule with antiangiogenic and antitumor properties. It functions as an S100A9 inhibitor and binds the HDAC4 Zn2+ domain with high affinity (Kd 10-30 nM) . This agent has been investigated in preclinical in vivo models for cancers like prostate carcinoma and in vitro for immunomodulatory effects.

Product Specifications

CAS Number

254964-60-8

Product Name Alternative

ABR215050, ABR-215050, ABR 215050, inhibit, HDAC4, HDAC, Inhibitor, Histone deacetylases, Tasquinimod

Field of Research

Epigenetics & Chromatin, Molecular Biology

Purity

98.30% (May vary between batches)

Solubility

2% DMSO+40% PEG300+5% Tween-80+53% Saline:1 mg/mL (2.46 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:9 mg/mL (22.15 mM) ; DMSO:65 mg/mL (159.96 mM)