AG-879
Tyrphostin AG 879 is a selective inhibitor of the HER2/ErbB2 tyrosine kinase, demonstrating potent activity with an IC50 of 1 μM. It exhibits 100- to 500-fold selectivity for HER2 over EGFR and PDGFR, making it a valuable tool for investigating HER2-driven signaling in cancer research, both in cellular and animal models.
Product Specifications
CAS Number
148741-30-4
Product Name Alternative
ErbB-1, ErbB2, EGFR, Epidermal growth factor receptor, HER2-Neu, HER1, Inhibitor, p75, inhibit, Apoptosis, Antitumor, antiproliferation, AG879, AG-879, AG 879, PDGFR, phosphorylation, Tyrphostin AG 879, Tyrphostin AG879, Tyrphostin AG-879, tyrosine, Tropomyosin related kinase receptor, Trkreceptor, Trk, Trk receptor, Trk Receptor, TrKA
Field of Research
Neuroscience
Purity
>98%
Bioactivity
NGFR kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) .
Smiles
CC (C) (C) c1cc (\C=C (/C#N) C (N) =S) cc (c1O) C (C) (C) C
Molecular Formula
C18H24N2OS
Molecular Weight
316.47
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3,5-Di-t-butyl-4-hydroxybenzylidene cyanothioacetamide
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