VU0361737
VU0361737 (ML-128) is a selective positive allosteric modulator of mGlu4 with EC50 values of 240 nM for human and 110 nM for rat receptors. It shows weak activity at mGlu5 and mGlu8, is inactive at other mGlu subtypes, crosses the blood-brain barrier, and is used in Parkinson's disease research involving in vitro and in vivo experiments.
Product Specifications
CAS Number
1161205-04-4
Product Name Alternative
Disease, inhibit, neuroprotective, ML128, ML-128, ML 128, Parkinson's, mGluR, mGluR4 (Human), mGluR4 (Rat), Metabotropic glutamate receptors, Inhibitor, VU0361737, VU-0361737, VU 0361737
Field of Research
Neuroscience
Purity
99.09% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2 mg/mL (7.61 mM) ; DMSO:45 mg/mL (171.3 mM)
Smiles
COc1cc (NC (=O) c2ccccn2) ccc1Cl
Molecular Formula
C13H11ClN2O2
Molecular Weight
262.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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