Lomibuvir
Lomibuvir (VCH-222) is a potent, non-nucleoside allosteric inhibitor of the Hepatitis C virus NS5B RNA-dependent RNA polymerase, exhibiting high affinity with a Kd of 17 nM. It demonstrates strong antiviral activity in HCV subgenomic replicon assays (EC50 = 5.2 nM) and preferentially blocks elongative RNA synthesis. This small molecule is a valuable tool for investigating HCV replication mechanisms in vitro.
Product Specifications
CAS Number
1026785-55-6
Product Name Alternative
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry
Purity
99.83% (May vary between batches)
Solubility
Ethanol:82 mg/mL (184.02 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:82 mg/mL (184.02 mM)
Smiles
CC1CCC (CC1) C (=O) N (C1CCC (O) CC1) c1cc (sc1C (O) =O) C#CC (C) (C) C
Molecular Formula
C25H35NO4S
Molecular Weight
445.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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