WYE-354
WYE-354 is a potent, selective, and ATP-competitive mTOR inhibitor with an IC50 of 5 nM. It effectively suppresses mTORC2-mediated P-AKT (S473) and mTORC1-mediated P-S6K (T389) signaling, demonstrating high selectivity over PI3K isoforms. This inhibitor is a valuable tool for investigating mTOR pathway biology in both cellular and in vivo cancer research models.
Product Specifications
CAS Number
1062169-56-5
Product Name Alternative
Autophagy, Apoptosis, inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, WYE 354, WYE-354, PI3Kα, WYE354, PI3Kγ
Field of Research
Cell Biology, Signal Transduction
Purity
97.86% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:92 mg/mL (185.66 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.02 mM)
Smiles
COC (=O) Nc1ccc (cc1) -c1nc (N2CCOCC2) c2cnn (C3CCN (CC3) C (=O) OC) c2n1
Molecular Formula
C24H29N7O5
Molecular Weight
495.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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