WZ-3146

WZ3146 is a potent, mutant-selective irreversible inhibitor targeting EGFR (L858R) and EGFR (E746_A750) with IC50 values of 2 nM each, while sparing ERBB2 phosphorylation (T798I) . It is a valuable chemical probe for studying oncogenic EGFR signaling in both cellular and animal models of non-small cell lung cancer.

Product Specifications

CAS Number

1214265-56-1

Product Name Alternative

Inhibit, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (E746_A750), EGFR (E746_A750/T790M), ErbB-1, Epidermal growth factor receptor, HER1, Inhibitor, WZ3146, WZ-3146, WZ 3146

Field of Research

Cardiovascular Research, Signal Transduction

Purity

97.15% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:86 mg/mL (184.97 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)