Bafilomycin A1
Bafilomycin A1 is a specific and reversible macrolide antibiotic that potently inhibits V-ATPase (IC50=0.44 nM) . It blocks autophagosome-lysosome fusion, arresting late-stage autophagy, and can induce apoptosis, making it a valuable tool for studying autophagy, cancer, and neurodegeneration in cellular and animal models.
Product Specifications
CAS Number
88899-55-2
Product Name Alternative
From Streptomyces griseus
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Vacuolar H+ ATPase inhibitor
Form
Lyophilized
Solubility
Soluble in DMSO (up to 50 mg/ml)
Smiles
[H][C@@]1 (OC (=O) \C (OC) =C\C (\C) =C\[C@@H] (C) [C@@H] (O) [C@@H] (C) C\C (C) =C\C=C\[C@@H]1OC) [C@@H] (C) [C@@H] (O) [C@H] (C) [C@@]1 (O) C[C@@H] (O) [C@H] (C) [C@H] (O1) C (C) C
Molecular Formula
C35H58O9
Molecular Weight
622.8
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(3Z,5E,7R,8S,9S,11E,13E,15S,16R) -8-hydroxy-16-[ (1S,2R,3S) -2-hydroxy-1-methyl-3-[ (2R,4R,5S,6R) -tetrahydro-2,4-dihydroxy-5-methyl-6- (1-methylethyl) -2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
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